HCID 66619363, compound → HCID 178499200, compound

HRID 417097Notes

Reaction equation

HRID 417097 reaction equation
[CH3:1][O:2][C:3]([C:5]1([O:8][C:9]2[CH:10]=[N:11][C:12]([O:15]CC3C=CC=CC=3)=[CH:13][CH:14]=2)[CH2:7][CH2:6]1)=[O:4]>C(O)C.[Pd]>[CH3:1][O:2][C:3]([C:5]1([O:8][C:9]2[CH:10]=[N:11][C:12]([OH:15])=[CH:13][CH:14]=2)[CH2:7][CH2:6]1)=[O:4]

Participants

4

Reactant 1

HCID 66619363HCID 66619363, compound

Product 1

HCID 178499200HCID 178499200, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 0.39 g (1.3 mmol) 1-(6-benzyloxy-pyridin-3-yloxy)-cyclopropanecarboxylic acid methyl ester in 4 mL ethanol, 39 mg 10% palladium on charcoal was added. The suspension was hydrogenated at 1.5 bar for 1 h. The catalyst was filtered off over Dicalite Speed Plus, washed with ethanol and the filtrate evaporated to dryness to the desired compound as a light brown solid (97%). MS (Turbo Spray): m/z=210.1 [M+H].

Workup

  1. filtrationThe catalyst was filtered off over Dicalite Speed Plus
  2. washwashed with ethanol
  3. customthe filtrate evaporated to dryness to the desired compound as a light brown solid (97%)

Sources & evidence

ORD record
ord-7c64434cf4bb4f39af09c94e4049ed97
Source dataset
uspto-grants-2012_01
Patent number
US08088930B2

Reaction notes

Loading…