Methyl 4-(bromomethyl)benzoate → 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-1,1-dimethyl-ethoxymethyl}-benzoic acid methyl ester

Participants

Reaction Steps

The title compound was prepared in analogy to Example 26, intermediate, from 1-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-1-cyclohexyl-2-methyl-propan-2-ol and methyl 4-(bromomethyl)benzoate (commercially available) to give the desired compound as a white solid (12%). MS (Turbo Spray): m/z=567.3 [M+H].

Provenance & Evidence