Methyl 4-(bromomethyl)-3-methoxybenzoate → HCID 66619379, compound

HRID 417104Notes

Reaction equation

HRID 417104 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:14][O:15]CC3CCCCC3)[C:11]3[CH:29]=[C:30]([F:34])[C:31]([F:33])=[CH:32][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.Br[CH2:36][C:37]1[CH:46]=[CH:45][C:40]([C:41]([O:43][CH3:44])=[O:42])=[CH:39][C:38]=1[O:47][CH3:48]>>[CH3:44][O:43][C:41](=[O:42])[C:40]1[CH:45]=[CH:46][C:37]([CH2:36][O:15][CH2:14][CH:13]([N:12]2[C:11]3[CH:29]=[C:30]([F:34])[C:31]([F:33])=[CH:32][C:10]=3[N:9]=[C:8]2[C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:38]([O:47][CH3:48])[CH:39]=1

Participants

3

Reactant 2

HCID 2759828Methyl 4-(bromomethyl)-3-methoxybenzoateHCID 666192022-(4-Chloro-phenyl)-1-(1-cyclohexyl-2-cyclohexylmethoxy-ethyl)-5,6-difluoro-1H-benzoimidazole2×

Product 1

HCID 66619379HCID 66619379, compound

Procedure

The title compound was prepared in analogy to Example 26, intermediate, from 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol (Example 1, intermediate c) and methyl 4-(bromomethyl)-3-methoxybenzoate (commercially available), to give the compound as light yellow solid (73%). MS (Turbo Spray): m/z=569.4 [M+H].

Sources & evidence

ORD record
ord-83d7ab3535e24c4784bb2f01da3cb01a
Source dataset
uspto-grants-2012_01
Patent number
US08088930B2

Reaction notes

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