反应详情

The title compound was prepared in analogy to Example 34, from 1-(2-bromo-1-cyclohexyl-ethyl)-2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 34, intermediate) and 4-(1-bromo-ethyl)-benzoic acid methyl ester (CAS RN: 16281-97-3). The residue was purified by preparative HPLC chromatography (phenomenex gemini column) eluting with a gradient of water:acetonitrile (100:0 to 5:95). Light yellow foam (22%). MS (Turbo Spray): m/z=553.3 [M+H].

1. customThe residue was purified by preparative HPLC chromatography (phenomenex gemini column)
2. washeluting with a gradient of water:acetonitrile (100:0 to 5:95)