N,N,N',N'-Tetramethylazodicarboxamide → HCID 66619245, compound

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Reaction Steps

The title compound was prepared in analogy to Example 4, intermediate, from 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol (Ex. 1, int. c), (4-hydroxy-2-methyl-phenoxy)-acetic acid (CAS RN 317319-10-1), tri-n-butylphosphin and N,N,N′,N′-tetramethylazodicarboxamide. The residue was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:ethyl acetate (100:0 to 70:30) to give the title compound as a light yellow foam (16%). MS (Turbo Spray): m/z=583.3 [M+H].

Provenance & Evidence