Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 4-{2-[2-(4-Chloro-2-methyl-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-3,5-difluoro-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| 반응물 | Methyl 3,5-difluoro-4-hydroxybenzoate | HCID 53847253 | — |
| 반응물 | HCID 178458272 | HCID 178458272 | — |
| 생성물 | 4-{2-[2-(4-Chloro-2-methyl-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-3,5-difluoro-benzoic acid methyl ester | HCID 66619220 | — |
반응 단계
The compound was prepared in analogy to Example 4, intermediate, from 2-[2-(4-chloro-2-methyl-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol (example 123, intermediate b), 3,5-difluoro-4-hydroxy-benzoic acid methyl ester (commercially available), triphenylphosphine and di-tert-butyl azodicarboxylate. The compound was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:ethyl acetate (100:0 to 70:30). Light yellow foam (37%). MS (Turbo Spray): m/z=575.4 [M+H].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088930B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-629e641a25194c89ae300ce4dac9d268 |
| 출처 메모 | uspto-grants-2012_01 |