HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-{2-[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-3,5-difluoro-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 3,5-Difluoro-4-hydroxy-benzonitrile | HCID 10749406 | — |
| Reactant | HCID 178458272 | HCID 178458272 | — |
| Product | 4-{2-[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-3,5-difluoro-benzonitrile | HCID 66619383 | — |
Reaction Steps
The title compound was prepared in analogy to Example 4, intermediate, from 2-[2-(4-chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-ethanol (Example 32, intermediate b), 3,5-difluoro-4-hydroxybenzonitrile (commercially available), triphenylphosphine and di-tert-butyl azodicarboxylate. The compound was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:ethyl acetate (100:0 to 70:30). Colorless foam. MS (Turbo Spray): m/z=492.4 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088930B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ccd5cd5c2deb4b77a47bb7904c597b9c |
| Source note | uspto-grants-2012_01 |