反应详情

To a solution of 3-butoxy-4-nitrobenzoic acid (City Chemicals) (2.5 g, 10.5 mmol) in methanol (10 mL) were added concentrated H2SO4 (1 g, 10.5 mmol). The reaction mixture was heated at reluxing for 2 h. The mixture was concentrated. The residue was partitioned between ethyl acetate and water. The organic layer was separated, and aqueous layer was extracted with ethyl acetate twice. The combined organic extract was washed with water, aqueous saturated NaHCO3 solution, brine, dried over MgSO4, and concentrated to give methyl 3-butoxy-4-nitrobenzoate as a brown oil (2.5 g, 95%).

1. temperatureThe reaction mixture was heated
2. concentrationThe mixture was concentrated
3. customThe residue was partitioned between ethyl acetate and water
4. customThe organic layer was separated
5. extractionaqueous layer was extracted with ethyl acetate twice
6. extractionThe combined organic extract
7. washwas washed with water, aqueous saturated NaHCO3 solution, brine
8. dry with materialdried over MgSO4
9. concentrationconcentrated