(2R)-2-Aminopropanamide hydrochloride → (R)-2-[3-(2-fluorobenzyl)-4-(2-fluorobenzyloxy)-benzylamino]propanamide

HRID 41735Notes

Reaction equation

HRID 41735 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[F:21])[CH:8]=O.Cl.[NH2:27][C@@H:28]([C:30]([NH2:32])=[O:31])[CH3:29]>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[F:21])[CH2:8][NH:27][C@H:28]([CH3:29])[C:30]([NH2:32])=[O:31]

Participants

3

Reactant 2

HCID 2775814(2R)-2-Aminopropanamide hydrochlorideHCID 866493293-(2-Fluorobenzyl)-4-(2-fluorobenzyloxy)benzaldehyde

Product 1

HCID 67125296(R)-2-[3-(2-fluorobenzyl)-4-(2-fluorobenzyloxy)-benzylamino]propanamide

Procedure

The compound of the title is prepared by reacting 3-(2-fluorobenzyl)-4-(2-fluorobenzyloxy)benzaldehyde (VIb) prepared as in Example 9a) with D-alaninamide hydrochloride according to the procedure of the Example 8b).

Workup

  1. customThe compound of the title is prepared

Sources & evidence

ORD record
ord-896875bb5ed543a1b403f31b845004f5
Source dataset
uspto-grants-2013_09
Patent number
US08530701B2

Reaction notes

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