HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Tert-butyl 2,6-dioxomorpholine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-(tert-Butoxycarbonyl)iminodiacetic Acid | HCID 2755971 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl 2,6-dioxomorpholine-4-carboxylate | HCID 11830836 | 99% |
Reaction Steps
A suspension of (tert-butoxycarbonyl-carboxymethyl-amino)-acetic acid (5 g, 21.4 mmol) and DCC (4.85 g, 23.6 mmol) in dichloromethane was stirred for 16 hours. The mixture was filtered and the solvent was removed from the filtrate to provide 2,6-dioxo-morpholine-4-carboxylic acid tert-butyl ester (4.86 g, 21.0 mmol, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088368B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-4c7e920d42894024a3a8363e9dc243ab |
| Source note | uspto-grants-2012_01 |