Potassium tert-butoxide → HCID 178470023, compound

HRID 41749Notes

Reaction equation

HRID 41749 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]([CH:19]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:20](=[O:31])NCC(OC(OC)=O)(C)C)[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1.CC(C)([O-])C.[K+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:19]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[C:20](=[O:31])[CH:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]3=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178472234HCID 178472234, compound

Product 1

HCID 178470023HCID 178470023, compound

Procedure

The compound was synthesized starting from ethyl 2-[(1H-benzo[d]imidazol-5-yl)[phenyl({2-[(methoxycarbonyl)oxy]-2-methylpropyl}carbamoyl)methyl]-carbamoyl]-acetate (which may be prepared in accordance with the procedure described for Intermediate 1; 0.3 g, 0.588 mmol) and potassium tert.-butoxide solution (1M, 1.18 ml, 1.176 mmol) according to the method described in step 2.

Workup

  1. customThe compound was synthesized
  2. custommay be prepared in accordance with the procedure

Sources & evidence

ORD record
ord-92dacbc9fe974a669a5387bd682f5e86
Source dataset
uspto-grants-2013_09
Patent number
US08530670B2

Reaction notes

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