Potassium tert-butoxide → HCID 178470024, compound

HRID 41750Notes

Reaction equation

HRID 41750 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]([CH:19]([C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[C:33]=3[F:39])[C:20](=[O:31])NCC(OC(OC)=O)(C)C)[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1.CC(C)([O-])C.[K+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:19]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[C:33]=4[F:39])[C:20](=[O:31])[CH:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]3=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178472235HCID 178472235, compound

Product 1

HCID 178470024HCID 178470024, compound

Procedure

The compound was synthesized starting from ethyl 2-[(1H-benzo[d]imidazol-5-yl)[2,3-difluorophenyl({2-[(methoxycarbonyl)oxy]-2-methylpropyl}carbamoyl)-methyl]-carba-moyl]acetate (which may be prepared in accordance with the procedure described for Intermediate 2; 0.134 g, 0.245 mmol) and potassium tert.-butoxide solution (1M, 0.49 ml, 0.49 mmol) according to the method described in step 2.

Workup

  1. customThe compound was synthesized
  2. custommay be prepared in accordance with the procedure

Sources & evidence

ORD record
ord-46e82acd5980409585f79790d36f56f1
Source dataset
uspto-grants-2013_09
Patent number
US08530670B2

Reaction notes

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