Potassium tert-butoxide → HCID 178470027, compound

HRID 41751Notes

Reaction equation

HRID 41751 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]([CH:19]([C:32]3[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([F:39])[C:33]=3[F:40])[C:20](=[O:31])NCC(OC(OC)=O)(C)C)[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1.CC(C)([O-])C.[K+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:19]([C:32]4[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([F:39])[C:33]=4[F:40])[C:20](=[O:31])[CH:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]3=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178472236HCID 178472236, compound

Product 1

HCID 178470027HCID 178470027, compound

Procedure

The compound was synthesized starting from ethyl 2-[(1H-benzo[d]imidazol-5-yl)[2,3,5-trifluorophenyl({2-[(methoxycarbonyl)oxy]-2-methylpropyl}carbamoyl)methyl]-carbamoyl]acetate (which may be prepared in accordance with the procedure described for Intermediate 3; 0.153 g, 0.271 mmol) and potassium tert.-butoxide solution (1M, 0.542 ml, 0.542 mmol) according to the method described in step 2.

Workup

  1. customThe compound was synthesized
  2. custommay be prepared in accordance with the procedure

Sources & evidence

ORD record
ord-d78911145eaf423f9f96874f66545cd1
Source dataset
uspto-grants-2013_09
Patent number
US08530670B2

Reaction notes

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