Potassium tert-butoxide → HCID 178470025, compound

HRID 41752Notes

Reaction equation

HRID 41752 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]([CH:19]([C:33]3[CH:38]=[CH:37][C:36]([N:39]4[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)=[CH:35][CH:34]=3)[C:20](=[O:32])NCC(OC(OC)=O)(CC)C)[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1.CC(C)([O-])C.[K+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:19]([C:33]4[CH:34]=[CH:35][C:36]([N:39]5[CH2:44][CH2:43][O:42][CH2:41][CH2:40]5)=[CH:37][CH:38]=4)[C:20](=[O:32])[CH:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]3=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178472233HCID 178472233, compound

Product 1

HCID 178470025HCID 178470025, compound

Procedure

The compound was synthesized starting from ethyl 2-[(1H-benzo[d]imidazol-5-yl)({[4-(morpholin-4-yl)phenyl]({2-[(methoxycarbonyl)oxy]-2-ethylpropyl}carbamoyl)methyl})-carbamoyl]acetate (which may be prepared in accordance with the procedure described for Intermediate 4; 0.38 g, 0.638 mmol) and potassium tert.-butoxide solution (1M, 1.276 ml, 1.276 mmol) according to the method described in Step 2.

Workup

  1. customThe compound was synthesized
  2. custommay be prepared in accordance with the procedure

Sources & evidence

ORD record
ord-fe5e70861cf247ca866a8ea68686aedc
Source dataset
uspto-grants-2013_09
Patent number
US08530670B2

Reaction notes

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