HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 417532Generated: October 31, 2026
Trimethylsilyldiazomethane → 1-(6-Bromonaphthalen-2-yl)-2-diazoethanone
https://huagongshe.com/reaction/417532
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 6-Bromo-2-naphthoyl chloride | HCID 21879606 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(6-Bromonaphthalen-2-yl)-2-diazoethanone | HCID 76818812 | — |
Reaction Steps
6-Bromonaphthalene-2-carbonyl chloride (27.0 g, crude) was dissolved in dichloromethane (330 mL) and cooled to 0° C. TMS diazomethane solution (100 mL, 2 M in DCM) was added, and ice bath was removed. Reaction mixture was stirred for 16 hours and evaporated under vacuum, giving 1-(6-bromonaphthalen-2-yl)-2-diazoethanone (34.7 g, crude) as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088368B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-d977e2a9992441cfa374ae85b92ed090 |
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| Source note | uspto-grants-2012_01 |
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