Trifluoro-methanesulfonic acid 8-trifluoromethanesulfonyloxy-6H-dibenzo[c,h]chromen-2-Y1 ester → HCID 66621380, compound

HRID 417696Notes

Reaction equation

HRID 417696 reaction equation
[CH3:1][O:2][C:3](=[O:60])[NH:4][CH:5]([C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]1[NH:17][C:18]([C:21]2[CH:22]=CC3C4C(=C5C=CC(C6NC(C7CCCN7C(=O)C(NC(OC)=O)C(C)C)=NC=6)=CC5=CC=4)[O:27][CH2:26][C:25]=3[CH:59]=2)=[CH:19][N:20]=1)=[O:10])[CH:6]([CH3:8])[CH3:7].FC(F)(F)S([O:66][C:67]1C=CC2[C:71]([CH:92]=1)=[CH:72][CH:73]=[C:74]1C=2OCC2C=C(OS(C(F)(F)F)(=O)=O)[CH:82]=[CH:83][C:75]1=2)(=O)=O>>[CH3:1][O:2][C:3](=[O:60])[NH:4][CH:5]([C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]1[NH:17][C:18]([C:21]2[CH:59]=[C:25]3[CH2:26][O:27][C:74]4[C:75]5=[C:92]([CH:71]=[C:72]([C:19]6[NH:20][C:16]([CH:12]7[CH2:13][CH2:14][CH2:15][N:11]7[C:9](=[O:10])[CH:5]([NH:4][C:3]([O:2][CH3:1])=[O:60])[CH:6]([CH3:7])[CH3:8])=[N:17][CH:18]=6)[CH:73]=4)[CH2:67][O:66][C:82]([CH:22]=2)=[C:83]35)=[CH:19][N:20]=1)=[O:10])[CH:6]([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 59610915Trifluoro-methanesulfonic acid 8-trifluoromethanesulfonyloxy-6H-dibenzo[c,h]chromen-2-Y1 esterHCID 66621320(1-{2-[5-(2-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-6-H-dibenzo[c,h]chromen-8-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Product 1

HCID 66621380HCID 66621380, compound

Procedure

Title compound was prepared according to the method employed to prepare (1-{2-[5-(2-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-6-H-dibenzo[c,h]chromen-8-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester, substituting trifluoro-methanesulfonic acid 7-trifluoromethane sulfonyloxy-5,10-dihydro-chromeno[5,4,3-cde]chromen-2-yl ester for trifluoro-methanesulfonic acid 2-trifluoromethanesulfonyloxy-6-H-dibenzo[c,h]chromen-8-yl ester.

Sources & evidence

ORD record
ord-96dc99d890444671bcfb6a87406f3c06
Source dataset
uspto-grants-2012_01
Patent number
US08088368B2

Reaction notes

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