Sodium Carbonate → HCID 25025698, compound

Participants

Reaction Steps

To a solution of N-[3-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-cyclopentyl]-3-bromo-benzenesulfonamide (66 mg, 0.153 mmol) in acetonitrile (2.5 mL), 2-fluorophenylboronic acid (35 mg, 0.25 mmol), [1,1′-bis(diphenylphosphino) ferrocene]dichloropalladium (20 mg, 0.024 mmol) and 2M Na2CO3 solution (2.5 mL) were added, the mixture was stirred for 30 seconds. The reaction was completed by microwave at 120° C. for ten minutes. The organic phase of the reaction mixture was filtered and purified by a reverse phase preparative HPLC, giving 26 mg (38%) 2′-fluoro-biphenyl-3-sulfonic acid [3-(4-Amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-cyclopentyl]-amide (6) as a white solid.

Provenance & Evidence