HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzoic Acid → 4-nitro-benzoic acid 3-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-cyclopentyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzoic Acid | HCID 6108 | — |
| Reactant | 4-Amino-5-fluoro-1-(3-hydroxy-cyclopentyl)-1H-pyrimidin-2-one | HCID 66649168 | — |
| Product | 4-nitro-benzoic acid 3-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-cyclopentyl ester | HCID 66649140 | — |
Reaction Steps
4-Amino-5-fluoro-1-(3-hydroxy-cyclopentyl)-1H-pyrimidin-2-one was inverted via the Mitsunobu reaction (General Method A) with 4-nitrobenzoic acid to provide 4-nitro-benzoic acid 3-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-cyclopentyl ester 28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093245B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-c55f5a1f4f3c42ff91daa1ab18bf7fc8 |
| Source note | uspto-grants-2012_01 |