HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 178508312, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 178447240 | HCID 178447240 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178508312 | HCID 178508312 | — |
Reaction Steps
A suspension of 2-(pivaloylamino)-pyrrolo[2,3-d]pyrimidine and ZnCl2 (3-20 equiv.) in wet EtOH (5 vol % water) was heated to 80 AC, and monitored by HPLC. When the reaction reached completion, DCM was added, and the organic layer was washed with sat. aq. NaHCO3 and brine. Drying (Na2SO4) and concentration afforded the desired 2-amino-pyrrolo[2,3-d]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093229B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-db056a0f55984af0957e69dd6f22aefe |
| Source note | uspto-grants-2012_01 |