HCID 57713867, compound → HCID 57713831, compound

HRID 417839Notes

Reaction equation

HRID 417839 reaction equation
[Cl:1][C:2]1[C:3]2[C:17]([C:18]#[C:19][CH2:20][N:21]([CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:16][N:15]([CH2:30][C:31]3[C:36]([CH3:37])=[C:35]([O:38][CH3:39])[C:34]([CH3:40])=[CH:33][N:32]=3)[C:4]=2[N:5]=[C:6]([NH:8]C(=O)C(C)(C)C)[N:7]=1>[Cl-].[Cl-].[Zn+2]>[Cl:1][C:2]1[C:3]2[C:17]([C:18]#[C:19][CH2:20][N:21]([CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:16][N:15]([CH2:30][C:31]3[C:36]([CH3:37])=[C:35]([O:38][CH3:39])[C:34]([CH3:40])=[CH:33][N:32]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

3

Reactant 1

HCID 57713867HCID 57713867, compound

Product 1

HCID 57713831HCID 57713831, compound

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

The title compound was prepared by cleaving the pivaloyl protecting group of N-[4-chloro-5-(3-diisobutylamino-prop-1-ynyl)-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide with ZnCl2 according to the General Procedure B. tR: 5.23 min. 1H-NMR (CDCl3) δ 8.23 (s, 1H), 7.08 (s, 1H), 5.31 (s, 2H), 4.99 (s, 1H), 3.76 (s, 3H), 3.56 (s, 2H), 2.29 (s, 31H), 2.27 (d, 4H), 2.21 (s, 31H), 1.74 (m, 2H), 0.90 (d, 12H).

Sources & evidence

ORD record
ord-5378f2441f9b41108abfa51683b19e67
Source dataset
uspto-grants-2012_01
Patent number
US08093229B2

Reaction notes

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