N-[4-Chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-5-trimethylsilanylethynyl-7H-pyrrolo [2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide → 4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-((trimethylsilyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	N-[4-Chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-5-trimethylsilanylethynyl-7H-pyrrolo [2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide	HCID 57713844	—
Catalyst	Zincchloride	HCID 3007855	—
Product	4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-((trimethylsilyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine	HCID 57713858	—

Reaction Steps

The title compound was prepared by cleaving the pivaloyl protecting group of N-[4-chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-5-trimethylsilanylethynyl-7H-pyrrolo[2,3-d]pyrimidin -2-yl]-2,2-dimethyl-propionamide with ZnCl2 according to the General Procedure B. tR=6.56 min. 1H NMR (CDCl3) δ 8.22 (s, 1H), 7.11 (s, 1H), 5.30 (s, 2H), 5.09 (s, 2H), 3.75 (s, 3H), 2.26 (s, 3H), 2.18 (s, 3H), 0.24 (s, 9H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093229B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-2f0e56b99f684ad58443ab142cb08d98
Source note	uspto-grants-2012_01