1-Methylpiperazine → 1-Methyl-4-(4-pentyn-1-yl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	Sodium Bicarbonate	HCID 516892	—
Reactant	Pent-4-yn-1-yl methanesulfonate	HCID 12476209	—
Solvent	1,2-Dichloroethane	HCID 11	—
Product	1-Methyl-4-(4-pentyn-1-yl)piperazine	HCID 23446116	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

A mixture of pent-4-ynyl methanesulfonate (887 mg) and N-methyl piperazine (607 μL) was heated to 80° C. for 4.5 h, diluted with 1,2-dichloroethane (5 mL) and heated to 70° C. for 18 h. Saturated aq. NaHCO3 was added (10 mL) and the mixture was extracted with DCM (3×40 mL), dried over Na2SO4, and concentrated to afford 1-methyl-4-(pent-4-ynyl)piperazine (0.23 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093229B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-963c90f4cfed405480e925000b37c54d
Source note	uspto-grants-2012_01