HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 417861Generated: October 26, 2026
1-Methylpiperazine → 1-Ethyl-4-(4-pentyn-1-yl)piperazine
https://huagongshe.com/reaction/417861
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Pent-4-yn-1-yl methanesulfonate | HCID 12476209 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 1-Ethyl-4-(4-pentyn-1-yl)piperazine | HCID 86608220 | — |
Reaction Steps
A mixture of pent-4-ynyl methanesulfonate (849 mg) and N-methyl piperazine (665 μL) was heated to 80° C. for 3 h, diluted with 1,2-dichloroethane (5 mL) and heated to 70° C. for 18 h. Saturated aq. NaHCO3 was added (10 mL) and the mixture was extracted with DCM (1×40 mL), dried over Na2SO4, and concentrated to afford 0.56 g of 1-ethyl-4-(pent-4-ynyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093229B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-d79befbc72c44742983260f1a91c0fdd |
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| Source note | uspto-grants-2012_01 |
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