HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(Pent-4-yn-1-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Pent-4-yn-1-yl methanesulfonate | HCID 12476209 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(Pent-4-yn-1-yl)piperazine | HCID 86608221 | 24% |
Reaction Steps
A solution of pent-4-ynyl methanesulfonate (19.55 g) and piperazine (41.5 g) in EtOH (80 mL) was heated to reflux for 1 h, and evaporated. The residue was taken in NaOH 2M (70 mL) and extracted with Et2O (70 mL). Evaporation gave 1-(pent-4-ynyl)piperazine (4.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093229B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-15d9f177399c4641b7ea0d4e41f8d113 |
| Source note | uspto-grants-2012_01 |