HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | Dichloromethane ethylacetate | HCID 21226138 | — |
| Reactant | 1-(Pent-4-yn-1-yl)piperazine | HCID 86608221 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 4-Nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate | HCID 86608222 | 64.8% |
Reaction Steps
A solution of 1-(pent-4-ynyl)piperazine (2.2 g) and Et3N (22 mL) in 1,2-dichloroethane (22 mL) was treated with p-nitrophenyl chloroformate (2.9 g) at rt for 10 min. Work-up and silica gel chromatography (DCM:EtOAc 1:3→0:3) gave 4-nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate as a yellow oil (2.96 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093229B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ac7df4b6e9f54d9aa0ec390acc7089cb |
| Source note | uspto-grants-2012_01 |