HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-Nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate | HCID 86608222 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide | HCID 86608223 | — |
Reaction Steps
A solution of 4-nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate (1.37 g) in THF (10 mL) was treated with 40% aq. MeNH2 (10 mL) at 70 C for 2 h. The mixture was concentrated and diluted with conc. NH4OH (5 mL) and water (15 mL). Extraction (DCM, 80 mL) and concentration gave N-methyl-4-(pent-4-ynyl)piperazine-1-carboxamide (0.659 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093229B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-0edfe2919b6240f0adf1ea6e6ad2e6ce |
| Source note | uspto-grants-2012_01 |