Ethyl isocyanate → N-ethyl-4-(pent-4-ynyl)piperazine-1-carboxamide

HRID 417867Notes

Reaction equation

HRID 417867 reaction equation
[CH2:1]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH2:2][CH2:3][C:4]#[CH:5].[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13]>C(Cl)Cl>[CH2:12]([NH:14][C:15]([N:9]1[CH2:8][CH2:7][N:6]([CH2:1][CH2:2][CH2:3][C:4]#[CH:5])[CH2:11][CH2:10]1)=[O:16])[CH3:13]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 866082211-(Pent-4-yn-1-yl)piperazine

Product 1

HCID 86608224N-ethyl-4-(pent-4-ynyl)piperazine-1-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1-(pent-4-ynyl)piperazine (1.08) in DCM (5 mL) was treated with ethyl isocyanate (0.56 mL) at rt for 2 h, and evaporated to yield N-ethyl-4-(pent-4-ynyl)piperazine-1-carboxamide.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-0f9002b4d30c41968ea71adceba7adc3
Source dataset
uspto-grants-2012_01
Patent number
US08093229B2

Reaction notes

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