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HRID417881

反应详情

EQUATION

反应方程式

HRID 417881 的结构方程式

REACTANTS

反应物

1
结构：COc1c(C)c[n+]([O-])c(Cn2cc(I)c3c(Cl)nc(NC(=O)C(C)(C)C)nc32)c1C
HCID86608229

未命名化合物

PRODUCTS

生成物

1
结构：COc1c(C)c[n+]([O-])c(Cn2cc(C#CCCO)c3c(Cl)nc(NC(=O)C(C)(C)C)nc32)c1C
HCID86608231

未命名化合物

收率 194.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C#CCCO
溶剂HCID13566

3-Butyn-1-ol

C4H6O

PROCEDURE

实验过程

Sonogashira coupling of 2-((4-chloro-5-iodo-2-pivalamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-4-methoxy-3,5-dimethylpyridine 1-oxide (335 mg) with but-3-yn-1-ol (200 μL) according to the general procedure A gave crude 2-((4-chloro-5-(4-hydroxybut-1-ynyl)-2-pivalamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)-4-methoxy-3,5-dimethylpyridine 1-oxide (291 mg).