Sodium t-butoxide → HCID 24956160, compound

Participants

Reaction Conditions

Reaction Steps

Following Method B, using 3,4-dihydro-2H-benzo[1,4]oxazin-6-ol hydrobromide (84 mg, 3.6 mmol), sodium tert-butoxide (125 mg, 1.3 mmol), Intermediate 5 (100 mg, 3.6 mmol), (But)3PBF4 (31 mg, 0.11 mmol) and palladium(II) acetate (12 mg, 0.055 mmol) in DME (2 mL) heated to 140° C. for 20 min under microwave irradiation. The crude material was purified by prep HPLC to give the title compound as a white solid (5 mg, 0.4%). δH (CDCl3) 1.11 (6H, s), 2.85 (2H, s), 3.12 (2H, s), 4.07-4.19 (2H, m), 4.20-4.30 (2H, m), 6.53-6.62 (1H, m), 6.80 (1H, d, J 8.85 Hz), 7.34-7.40 (1H, m). LCMS (ES+) 346 (M+H)+.

Provenance & Evidence