Morpholine → HCID 24956520, compound

Participants

Reaction Conditions

Reaction Steps

Using Example 7 (50 mg, 0.14 mmol), morpholine (1.2 mL, 1.15 mmol), sodium tert-butoxide (41 mg, 0.43 mmol), palladium(II) acetate (2 mg, 0.007 mmol) and (But)3PBF4 (0.004 g, 0.014 mmol) in THF (3 mL) heated to 140° C. under microwave irradiation, for 60 min. The crude material was purified by prep HPLC to give the title compound as an off-white solid (5 mg, 11%). δH (CDCl3) 1.15 (6H, s), 2.43 (2H, s), 2.75 (2H, s), 3.04-3.12 (4H, m), 3.83-3.91 (4H, m), 4.20-4.25 (2H, m), 4.26-4.31 (2H, m), 6.70 (1H, dd, J 9.0, 2.8 Hz), 6.89 (1H, d, J 9.0 Hz), 7.41 (1H, d, J 2.6 Hz). LCMS (ES+) 400 (M+H)+.

Provenance & Evidence