1-Methylpiperazine → HCID 66648568, compound

Participants

Reaction Conditions

Reaction Steps

Using Example 7 (50 mg, 0.14 mmol), 1-methylpiperazine (0.12 mL, 1.15 mmol), sodium tert-butoxide (41 mg, 0.43 mmol), palladium(II) acetate (2 mg, 0.007 mmol) and (But)3PBF4 (4 mg, 0.014 mmol) in THF (3 mL) heated to 140° C. under microwave irradiation for 20 min. The crude material was purified by prep HPLC to give the title compound as an off-white solid (6 mg, 8%). δH (CDCl3) 1.15 (6H, s), 2.37 (3H, s), 2.42 (2H, s), 2.56-2.65 (4H, m), 2.75 (2H, s), 3.09-3.18 (4H, m), 4.25-4.31 (2H, m), 4.18-4.25 (2H, m), 6.72 (1H, dd, J 8.9, 2.6 Hz), 6.87 (1H, d, J 8.9 Hz), 7.41 (1H, d, J 2.8 Hz). LCMS (ES+) 413 (M+H)+.

Provenance & Evidence