2-Bromoethyl methyl ether → HCID 42633095, compound

Participants

Reaction Conditions

Reaction Steps

2-(piperazin-1-yl)ethyl 4-phenylpiperazine-1-carboxylate (None HCl salt of Example 30; 311 mg, 0.98 mmol) was dissolved in DMF (2 mL). 2-bromoethyl methyl ether (92 μl, 0.98 mmol) and DIPEA (0.3 mL, 1.72 mmol) were added and the reaction mixture was heated at 170° C. for 15 minutes in a Biotage Initiator microwave at high absorption. The reaction mixture was concentrated in vacuo, dissolved in 1 M aq Na2CO3 solution (25 mL) and extracted with DCM (3×25 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by normal phase column chromatography (eluting with DCM, followed by a 200:8:1 mixture of DCM:EtOH:NH3) to give 2-(4-(2-methoxyethyl)-piperazin-1-yl)ethyl 4-phenylpiperazine-1-carboxylate (163 mg, 44%) as a yellow oil.

Provenance & Evidence