HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 8-Phenyl-2-(4-pyridinyl)-6,7,8,9-tetrahydro-4H-pyrimido[1.2-a]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 3-(4-pyridyl)-3-oxopropionate | HCID 2735202 | — |
| Reactant | 4-Phenyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride | HCID 23026152 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Phenyl-2-(4-pyridinyl)-6,7,8,9-tetrahydro-4H-pyrimido[1.2-a]pyrimidin-4-one | HCID 135780266 | 98% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A suspension containing 4 g (16.12 mmoles) of 6-phenyl-1,4,5,6-tetrahydro-2-pyrimidinamine hydrochloride (1:2), 3.11 g (16.12 mmoles) of ethyl 3-(pyridin-4-yl)-3-oxopropionate, 6.68 g (48.36 mmoles) of anhydrous potassium carbonate in 50 ml of ethanol were refluxed for 18 h. The cooled solution was evaporated and the residue was treated with water and allowed to stir at 0° C. during 2 h. The precipitate which formed was recovered by filtration and dried at 90° C. during 18 h. 4.80 g (98%) of product was thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093256B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-f02df84d91e64174a1499924c44f298e |
| Source note | uspto-grants-2012_01 |