Hydrochloric Acid → 4-{2-(2-Carboxy-ethyl)-3-[6-(3-methanesulfonyl-5-thiazol-4-yl-phenoxy)-hexyl]-phenoxy}-butyric Acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-methanesulfonyl-5-thiazol-4-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (280 mg, 0.434 mmol) in EtOH (20 mL), 3N NaOH (1 mL) was added and heated at 70° C. for 2 h. The reaction was acidified with 3N HCl (1.1 mL). Concentration under reduced pressure gave an oil. Preparative HPLC provided title compound (119 mg, 46% yield). LC/MS indicated a purity of 92% as measured by UV 214 nM. HR-ES(+): calculated for C29H36NO8S2 (M+H)1+ 590.1877, found 590.1876.

Provenance & Evidence