Sodium Hydroxide → 4-{2-(2-Carboxy-ethyl)-3-[6-(3-methanesulfonyl-5-pyrimidin-4-yl-phenoxy)-hexyl]-phenoxy}-butyric Acid

Participants

Reaction Steps

Title compound was prepared according to a similar procedure described in Example 21, step 2 by reaction of 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-methanesulfonyl-5-pyrimidin-4-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (164 mg) with 3 N NaOH (1 mL). Preparative HPLC provided the title compound. LC/MS indicated a purity of 84% as measured by UV 214 nM. HR-ES(+): calculated for C30H37N2O8S (M+H)1+ 582.2265, found 585.2267.

Provenance & Evidence