HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 57863112, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,4-Difluorobenzeneboronic acid | HCID 2734337 | — |
| Reactant | 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-methanesulfonyl-phenoxy)-hexyl]-phenoxy}-butyric Acid Ethyl Ester | HCID 57863037 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 57863112 | HCID 57863112 | 42.2% |
Reaction Steps
A similar procedure as described in Example 41, step 1 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-methanesulfonyl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (500 mg, 0.73 mmol), 3,4-difluorophenylboronic acid (236 mg, 1.45 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (79.7 mg, 0.109 mmol), and cesium carbonate (477.9 mg, 1.45 mmol) to afford 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-methanesulfonyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (207 mg, 42.2%) as a light yellow viscous oil: ES(+)-HRMS m/e calcd for C36H44F2O8S (M+Na)+ 697.2617, found 697.2611.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093253B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-62aacabd21f842d1ab3cf8a170eaef9b |
| Source note | uspto-grants-2012_01 |