Sodium Hydroxide → HCID 57863064, compound

Participants

Reaction Steps

A similar procedure as described in Example 40, step 8 was used, starting from 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-methanesulfonyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (200 mg, 0.296 mmol) and 1.0 N aqueous sodium hydroxide (2.96 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-methanesulfonyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (92 mg, 50%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C32H36F2O8S (M+Na)+ 641.1991, found 641.1988.

Provenance & Evidence