HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 57863029, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-(Methanesulfonyl)phenylboronic acid | HCID 2734364 | — |
| Reactant | 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-methanesulfonyl-phenoxy)-hexyl]-phenoxy}-butyric Acid Ethyl Ester | HCID 57863037 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 57863029 | HCID 57863029 | 26.8% |
Reaction Steps
A similar procedure as described in Example 41, step 1 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-methanesulfonyl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (257 mg, 0.37 mmol), 4-methanesulfonylphenylboronic acid (153.8 mg, 0.75 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (40.9 mg, 0.056 mmol), and cesium carbonate (245.5 mg, 0.75 mmol) to afford 4-[3-[6-(5,4′-bis-methanesulfonyl-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (71 mg, 26.4%) as a light brown viscous oil: ES(+)-HRMS m/e calcd for C37H48O10S2 (M+H)+ 717.2762, found 717.2758.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093253B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-37587f5f00c045b080d4ec25b988a530 |
| Source note | uspto-grants-2012_01 |