反应详情

A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(3-benzo[1,3]dioxol-5-yl-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (200 mg, 0.28 mmol) and 1.0 N aqueous sodium hydroxide (5 mL) to afford 4-[3-[6-(3-benzo[1,3]dioxol-5-yl-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (151 mg, 82%) as an amorphous white solid, mp=134-135° C.: ES(+)-HRMS m/e calcd for C34H40O10S (M+Na)+ 663.2234, found 663.2235.