反应详情

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-[6-(3-bromo-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (150 mg, 0.23 mmol), 3,4-difluorophenylboronic acid (72 mg, 0.46 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (29 mg, 0.04 mmol), and cesium carbonate (149 mg, 0.46 mmol) to afford 4-[3-[6-(5-ethanesulfonyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (148 mg, 94%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C37H46F2O8S (M+Na)+ 711.2773, found 711.2778.