Sodium Hydroxide → 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethanesulfonyl-3',4'-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid

Participants

Reaction Steps

A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(5-ethanesulfonyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (137 mg, 0.198 mmol) and 1.0 N aqueous sodium hydroxide (5 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-ethanesulfonyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (102 mg, 82%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C33H38F2O8S (M+H)+ 633.2328, found 633.2327.

Provenance & Evidence