反应详情

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-[6-(3-bromo-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (213 mg, 0.32 mmol), 4-fluoro-3-hydroxy-phenylboronic acid (101 mg, 0.64 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (37 mg, 0.05 mmol), and cesium carbonate (317 mg, 0.97 mmol) to afford 4-[3-[6-(5-ethanesulfonyl-4′-fluoro-3′-hydroxy-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (218 mg, 99%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C37H47FO9S (M+Na)+ 709.2817, found 709.2817.