Sodium Hydroxide → 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4'-fluoro-3'-hydroxy-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid

Participants

Reaction Steps

A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(5-ethanesulfonyl-4′-fluoro-3′-hydroxy-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (218 mg, 0.32 mmol) and 1.0 N aqueous sodium hydroxide (5 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4′-fluoro-3′-hydroxy-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (173 mg, 87%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C33H39FO9S (M+Na)+ 653.2191, found 653.2194.

Provenance & Evidence