Sodium Hydroxide → 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4'-chloro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid

Participants

Reaction Steps

A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(5-ethanesulfonyl-4′-chloro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (116 mg, 0.17 mmol) and 1.0 N aqueous sodium hydroxide (1.7 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4′-chloro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (106 mg, 99%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C33H39ClO8S (M+Na)+ 653.1946, found 653.1948.

Provenance & Evidence