HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4'-fluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[3-[6-(5-Ethanesulfonyl-4'-fluoro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester | HCID 57863019 | — |
| Product | 4-[2-(2-Carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4'-fluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid | HCID 57863109 | 48.8% |
Reaction Steps
A similar procedure as described in Example 40, step 8 was used, starting from 4-[3-[6-(5-ethanesulfonyl-4′-fluoro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (115 mg, 0.17 mmol) and 1.0 N aqueous sodium hydroxide (1.7 mL) to afford 4-[2-(2-carboxy-ethyl)-3-[6-(5-ethanesulfonyl-4′-fluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid (51 mg, 48%) as an amorphous white solid: ES(+)-HRMS m/e calcd for C33H39FO8S (M+Na)+ 637.2242, found 637.2242.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093253B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-009fcd4df196432f91f15dce40101ee0 |
| Source note | uspto-grants-2012_01 |