Cesium carbonate → HCID 57863120, compound

Participants

Reaction Steps

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-[6-(3-bromo-5-ethanesulfonyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (154 mg, 0.23 mmol), 3-thiopheneboronic acid (60.2 mg, 0.47 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (26 mg, 0.035 mmol), and cesium carbonate (155 mg, 0.47 mmol) to afford 4-[3-[6-(3-ethanesulfonyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (117 mg, 76%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C35H46O8S2 (M+Na)+ 681.2526, found 681.2526.

Provenance & Evidence