Cesium carbonate → HCID 57863086, compound

Participants

Reaction Steps

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-{6-[3-bromo-5-(propane-1-sulfony)-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (208 mg, 0.31 mmol), 3,4-(methylenedioxyphenyl)boronic acid (103 mg, 0.62 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (34 mg, 0.046 mmol), and cesium carbonate (205 mg, 0.62 mmol) to afford 4-[3-{6-[3-benzo[1,3]dioxol-5-yl-5-(propane-1-sulfonyl)-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (95 mg, 43%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C39H50O10S (M+Na)+ 733.3017, found 733.3011.

Provenance & Evidence