Cesium carbonate → HCID 57863110, compound

Participants

Reaction Steps

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-[6-(3-bromo-5-(propane-1-sulfonyl)-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (220 mg, 0.33 mmol), 3,4-difluoro-phenylboronic acid (107 mg, 0.66 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (36 mg, 0.05 mmol), and cesium carbonate (217 mg, 0.66 mmol) to afford 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-(propane-1-sulfonyl)-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (142 mg, 62%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C38H48F2O8S (M+Na)+ 725.2930, found 725.2928.

Provenance & Evidence