Cesium carbonate → HCID 57863115, compound

Participants

Reaction Steps

A similar procedure as described in Example 41, step 1 was used, starting from 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-bromo-5-(propane-1-sulfonyl)-phenoxy)-hexyl]-phenoxy]-butyric acid ethyl ester (208 mg, 0.31 mmol), 3-thiopheneboronic acid (81.2 mg, 0.62 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (34 mg, 0.047 mmol), and cesium carbonate (205 mg, 0.62 mmol) to afford 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-(propane-1-sulfonyl)-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy]-butyric acid ethyl ester (152 mg, 73%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C36H48O8S2 (M+Na)+ 695.2683, found 695.2680.

Provenance & Evidence