Cesium carbonate → HCID 57863028, compound

Participants

Reaction Steps

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-{6-[3-bromo-5-(propane-2-sulfony)-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (175 mg, 0.26 mmol), 3,4-(methylenedioxyphenyl)boronic acid (86.6 mg, 0.52 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (28.7 mg, 0.039 mmol), and cesium carbonate (171.8 mg, 0.52 mmol) to afford 4-[3-{6-[3-benzo[1,3]dioxol-5-yl-5-(propane-2-sulfonyl)-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (147 mg, 79%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C39H50O10S (M+Na)+ 733.3017, found 733.3017.

Provenance & Evidence